The interoperability of chemical and biological crystallographic data is a key challenge to research and its Fenders (Rear) application to pharmaceutical design.Research attempting to combine data from the two disciplines, small-molecule or chemical crystallography (CX) and macromolecular crystallography (MX), will face unique challenges including
Abstract Background Critically ill patients frequently experience severe agitation placing them at risk of harm.Physical restraint is 6RB common in intensive care units (ICUs) for clinician concerns about safety.However, physical restraint may not prevent medical device removal and has been associated with negative physical and psychological conseq
Individuals with inclusion body myopathy type 3 (IBM3) display ילדים congenital joint contractures with early-onset muscle weakness that becomes more severe in adulthood.The disease arises from an autosomal dominant point mutation causing an E706K substitution in myosin heavy chain type IIa.We have previously expressed the corresponding myosin